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Dendritic cell interactions with Histoplasma and Paracoccidioides

Sharanjeet K Thind1, Carlos P Taborda, Joshua D Nosanchuk

  • 1a Department of Medicine [Division of Infectious Diseases]; SUNY Downstate Medical Center ; Brooklyn , NY , USA.

Virulence
|May 2, 2015
PubMed

Insights

Dendritic cells (DCs) are crucial for controlling fungal infections. This review highlights their role in bridging innate and adaptive immunity against fungi like Histoplasma and Paracoccidioides.

Area of Science:

  • Immunology
  • Mycology
  • Microbiology

Background:

  • Fungi are common environmental microbes, with over 100,000 species identified.
  • While most fungi are harmless, some cause severe infections, particularly in immunocompromised individuals.
  • Environmental changes can increase exposure to fungal spores, affecting both immunocompromised and healthy individuals.

Purpose of the Study:

  • To review the general role of dendritic cells (DCs) in immunity.
  • To illustrate the specific interactions between DCs and dimorphic fungi, Histoplasma and Paracoccidioides.
  • To highlight DCs as a bridge between innate and adaptive immune responses against fungal pathogens.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Focuses on the immunological mechanisms involving dendritic cells.
  • Examines the interaction of DCs with specific dimorphic fungi.

Main Results:

  • Dendritic cells play a fundamental role in resolving fungal infections.
  • DCs act as crucial intermediaries connecting innate and adaptive immunity.
  • Specific interactions with Histoplasma and Paracoccidioides demonstrate DC importance.

Conclusions:

  • Dendritic cells are vital for effective immune responses to fungal infections.
  • Understanding DC function is key to developing strategies against mycoses.
  • DCs are central to host defense against challenging fungal pathogens.
Keywords:
DC, dentritic cells(s)HKHC, heat-killed H.capsulatumHistoplasmaPAMP, pathogen-associated molecular patternsPCM, paracoccidioidomycosisPRR, pattern recognition receptorsParacoccidioidesTLR, toll-like receptordendritic cellimmunoresponse

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