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Construction of a functional thymic microenvironment from pluripotent stem cells for the induction of central

Nicholas Bredenkamp1, Xin Jin, Dong Liu

  • 1MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, SCRM Building, 5 Little France Drive, Edinburgh, EH16 4UU, UK.

Regenerative Medicine
|May 2, 2015
PubMed

The thymus is required for generation of a self-tolerant, self-restricted T-cell repertoire. The capacity to manipulate or replace thymus function therapeutically would be beneficial in a variety of clinical settings, including for improving recovery following bone marrow transplantation, restoring immune system function in the elderly and promoting tolerance to transplanted organs or cells. An attractive strategy would be transplantation of thymus organoids generated from cells produced in vitro, for instance from pluripotent stem cells. Here, we review recent progress toward this goal, focusing on advances in directing differentiation of pluripotent stem cells to thymic epithelial cells, a key cell type of the thymic stroma, and related direct reprogramming strategies.

Keywords:
direct reprogrammingdirected differentiationmicroenvironmentpluripotent stem cellprogenitor cellstem cellthymic epithelial cellthymus

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