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Updated: Apr 13, 2026
08:49
Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
Published on: March 14, 2021
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Phosphatidylserine and the human brain
1The Nutrition Doctor, Kailua-Kona, Hawaii.
Nutrition (Burbank, Los Angeles County, Calif.)
|May 3, 2015
Summary
Phosphatidylserine (PS) is essential for brain health and cognitive function. Supplementation with PS can improve memory, learning, and attention, while also supporting nerve cell structure and function in aging brains.
Area of Science:
- Neuroscience
- Biochemistry
- Nutritional Science
Background:
- Phosphatidylserine (PS) is an endogenous phospholipid vital for cell membrane structure and function.
- Cognitive decline with aging is linked to biochemical and structural changes in the brain.
- PS plays a role in neurotransmission and overall brain health.
Purpose of the Study:
- To evaluate the significance of phosphatidylserine (PS) in human brain biochemistry, physiology, and function.
- To review the existing scientific literature on PS and its effects on the brain.
Main Methods:
- A comprehensive literature search was performed using MEDLINE.
- Articles published before June 2014 concerning PS and the human brain were reviewed.
- 127 relevant articles were selected for this review.
Main Results:
- Significant scientific evidence links phosphatidylserine (PS) to cognitive activity, cognitive aging, and the maintenance of cognitive abilities.
- Interactions between PS, cognitive function, and aging processes are well-documented.
Conclusions:
- Phosphatidylserine (PS) is crucial for maintaining healthy nerve cell membranes and myelin sheaths.
- Exogenous PS is efficiently absorbed, crosses the blood-brain barrier, and can mitigate age-related brain deterioration.
- PS supplementation supports various cognitive functions, including memory, learning, attention, and problem-solving, as well as motor functions.
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