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Nutrient intake in neurofibromatosis type 1: A cross-sectional study
Marcio Leandro Ribeiro de Souza1, Ann Kristine Jansen1, Aline Stangherlin Martins1
1Federal University of Minas Gerais, Brazil.
Nutrition (Burbank, Los Angeles County, Calif.)
|May 3, 2015
Summary
Adults with neurofibromatosis type 1 (NF1) exhibit poor nutrition, with most consuming insufficient energy, fiber, vitamins, and minerals. Their diets are excessively high in fats and sodium, indicating a need for dietary intervention.
Area of Science:
- Nutritional Science
- Genetics
- Clinical Medicine
Background:
- Neurofibromatosis type 1 (NF1) is a genetic disorder with complex clinical manifestations.
- Nutritional status is crucial for managing chronic conditions like NF1.
- Limited data exists on the specific dietary patterns of adult NF1 patients.
Purpose of the Study:
- To assess the nutrient intake of adult patients diagnosed with neurofibromatosis type 1 (NF1).
Main Methods:
- A cross-sectional study involved 60 adult NF1 patients (29 males, 31 females).
- Nutritional assessment included anthropometric measurements and dietary data collection via three non-consecutive 24-hour recalls.
- Nutrient intake was analyzed against Dietary Reference Intake (DRI) recommendations.
Main Results:
- 72% of NF1 patients had energy intake below Estimated Energy Requirements (EER), with men being significantly more affected (86.2%) than women (58.1%).
- Inadequate intake of vitamin D, magnesium, calcium, and pyridoxine was common.
- All patients consumed excess sodium, and diets were deficient in fiber, vitamins A and C, with excessive saturated fatty acids and lipids.
Conclusions:
- Adult NF1 patients demonstrate suboptimal dietary patterns, characterized by high fat and sodium content, and low intake of essential micronutrients and fiber.
- These findings highlight the need for targeted nutritional interventions in NF1 management.
- Further research is warranted to explore the relationship between these dietary habits and NF1 clinical severity.
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