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Related Concept Videos

Ion Exchange01:17

Ion Exchange

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Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Cationic Chain-Growth Polymerization: Mechanism00:57

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The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

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The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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Cationic β-cyclodextrin polymer applied to a dual cyclodextrin polyelectrolyte multilayer system.

Jatupol Junthip1, Nicolas Tabary1, Laurent Leclercq2

  • 1Université Lille 1, Unité Matériaux et Transformations (UMET) UMR CNRS 8207, Villeneuve d'Ascq, France.

Carbohydrate Polymers
|May 3, 2015
PubMed
Summary

Researchers developed a novel cationic polymer using β-cyclodextrin for textile coatings. This polyelectrolyte multilayer film (PEM) shows promise for future drug delivery applications.

Keywords:
Drug delivery systemEpichlorohydrinLayer-by-layerPolyelectrolytes multilayer system (PEM)Textileβ-Cyclodextrin-polymer

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Polyelectrolyte multilayer films (PEMs) are versatile for surface modification.
  • β-cyclodextrin (βCD) based polymers offer unique properties for drug delivery.
  • Textile functionalization is crucial for advanced applications like drug delivery.

Purpose of the Study:

  • To synthesize a novel cationic β-cyclodextrin polymer for PEM fabrication.
  • To develop a PEM coating on a textile substrate for drug delivery.
  • To investigate the optimization of polymer synthesis and layer-by-layer deposition.

Main Methods:

  • Synthesis of cationic β-cyclodextrin polymer (polyEPG-CD) via crosslinking.
  • Characterization using FTIR, NMR, colloidal titration, conductimetry, TGA, and SEC.
  • Layer-by-layer (LbL) deposition of PEM onto textile using dip coating.
  • Monitoring of multilayer self-assembly via SEM, gravimetry, and OWLS.

Main Results:

  • Successfully synthesized a water-soluble cationic β-cyclodextrin polymer with optimal properties for LbL deposition.
  • Fabricated a PEM coating on a textile substrate using cationic polyEPG-CD and anionic polyCTR-CD.
  • Characterized the PEM structure and assembly process, discussing the influence of solution parameters.

Conclusions:

  • A novel cationic β-cyclodextrin polymer was developed and characterized.
  • A functional PEM coating was successfully applied to a textile substrate.
  • The developed material holds potential for future drug delivery applications.