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Updated: Apr 13, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
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Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

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Molecular pathways and therapies in autosomal-dominant polycystic kidney disease

Takamitsu Saigusa1, P Darwin Bell2

  • 1Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina; and Ralph Johnson VA Medical Center, Charleston, South Carolina.

Physiology (Bethesda, Md.)
|May 3, 2015
PubMed

Insights

Autosomal-dominant polycystic kidney disease (ADPKD) is a common inherited kidney disorder causing cysts and potential kidney failure. Research on primary cilia and polycystins advances understanding of ADPKD pathogenesis and therapeutic targets.

Area of Science:

  • Nephrology
  • Genetics
  • Cell Biology

Background:

  • Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited renal disorder.
  • ADPKD is characterized by the development of multiple kidney cysts, often leading to kidney failure.
  • Primary cilia and polycystins are key factors in ADPKD pathogenesis.

Purpose of the Study:

  • To review the clinical and basic aspects of ADPKD.
  • To discuss current concepts regarding the pathogenesis of ADPKD.
  • To evaluate potential therapeutic targets and future clinical study challenges.

Main Methods:

  • Literature review of clinical and basic research on ADPKD.
  • Synthesis of current understanding of ADPKD pathogenesis.
  • Analysis of potential therapeutic strategies and research directions.

Main Results:

  • ADPKD is a prevalent inherited renal disease with significant morbidity.
  • Primary cilia dysfunction and polycystin mutations are central to cyst formation.
  • Understanding pathogenesis guides the identification of therapeutic targets.

Conclusions:

  • ADPKD pathogenesis is increasingly understood through research on cilia and polycystins.
  • Targeting specific pathways offers potential therapeutic avenues.
  • Further clinical studies are needed to overcome challenges and develop effective treatments.

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