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uSIMPK. An Excel for Windows-based simulation program for instruction of basic pharmacokinetics principles to
1Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Computer Methods and Programs in Biomedicine
|May 3, 2015
Summary
This study introduces an interactive computer program to teach pharmacokinetics. The software simplifies complex drug concentration dynamics, enhancing student understanding of physiological and dosing impacts.
Area of Science:
- Pharmacology
- Educational Technology
Background:
- Pharmacokinetics (PK) presents teaching challenges due to complex interrelationships.
- Understanding drug concentration-time curves requires integrating physiological parameters and mathematical models.
Purpose of the Study:
- To develop a computer-based instructional tool for teaching basic pharmacokinetics.
- To illustrate the impact of PK and physiological parameters on drug concentration profiles.
Main Methods:
- A Microsoft Excel-based program with linked modules using Visual Basic for Applications.
- Interactive simulations with user guides allowing parameter manipulation.
- Utilized 'slider' bars for dynamic visualization of parameter changes.
Main Results:
- The program effectively demonstrates relationships between PK parameters, doses, and drug concentration-time curves.
- Covers diverse PK concepts including single/repeated dosing, clearance, nonlinear elimination, and multi-compartment models.
- Positive student feedback indicates enhanced learning and engagement.
Conclusions:
- The developed software serves as a valuable aid for instructing entry-level pharmacy students in pharmacokinetics.
- Interactive simulation enhances comprehension of complex PK principles and their clinical relevance.
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