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[Functional state of blood platelets in arterial hypertension and the changes in serotonin-containing cellular
Insights
Patients with essential hypertension exhibit significantly reduced platelet granules and serotonin levels, impacting platelet function. This suggests a potential link between granular apparatus abnormalities and hypertension pathophysiology.
Area of Science:
- Hematology
- Cardiovascular Medicine
- Cell Biology
Context:
- Arterial hypertension (AH) is a major cardiovascular risk factor.
- Platelet function and granular content are crucial in hemostasis and thrombosis.
- Alterations in platelet structure and function may contribute to AH pathogenesis.
Purpose:
- To investigate the status of the granular apparatus and platelet aggregability in patients with arterial hypertension (AH).
- To compare platelet characteristics between healthy donors and individuals with essential hypertension (EH) and symptomatic AH.
- To explore the relationship between platelet granule volume, serotonin levels, and platelet function in EH.
Summary:
- Patients with essential hypertension (EH) showed significantly reduced relative volumes of electron-dense platelet granules compared to healthy controls.
- Lower platelet serotonin levels and decreased acridine orange transport across platelet membranes were observed in EH patients.
- A strong positive correlation was found between platelet serotonin content and the relative volume of platelet granules in EH patients.
Impact:
- Findings suggest that abnormalities in platelet granular content and serotonin storage are associated with essential hypertension.
- This research highlights potential mechanisms linking platelet dysfunction to the pathophysiology of arterial hypertension.
- The study provides a basis for further investigation into platelet-based biomarkers and therapeutic targets for hypertension.
Abstract:
The study was undertaken to examine the status of the granular apparatus and platelet aggregability in 9 healthy donors and 18 patients with arterial hypertension (AH), including 14 with essential hypertension (EH) and 4 with symptomatic forms of AH. Among the patients, a group of 8 EH patients was singled out, who had, compared with normal, reduced relative volumes of electron dense platelet granules (from 17.9 +/- 2.0 to 5.3 +/- 0.6%). The group also showed lower platelet serotonin levels (from 67.3 +/- 5.3 to 17.6 +/- 3.7 ng per 10(8) cells; p less than 0.001) and a 2-fold decrease in the transport factor of acridine orange across the cytoplasmic and granular membranes as compared to normal. A positive correlation was established between the amounts of cellular serotonin and the relative volume of platelet granules (r = 0.850; p less than 0.001).