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Updated: Apr 13, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
Allergic rhinitis phenotypes based on mono-allergy or poly-allergy
Matteo Gelardi1, Giorgio Ciprandi, Cristoforo Incorvaia
1Section of Otolaryngology, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy.
Background:
Allergic rhinitis (AR) is characterized by typical symptoms that are dependent on inflammation. Poly-allergy is a frequent phenomenon. Phenotyping AR represents an up-to-date issue.
Objective:
The aim of this study was to evaluate whether the number of allergies is able to define different phenotypes in patients with AR.
Methods:
83 patients (43 males, mean age 34.7 years) suffering from AR were evaluated. Sensitization, VAS for nasal symptoms perception, and nasal cytology were evaluated.
Results:
Poly-allergic patients perceived more severe nasal obstruction than mono-allergic ones (p = 0.0006) as well as they had more frequent sneezing (p < 0.0001). Moreover, poly-allergic patients had a more intense inflammatory infiltrate, concerning both eosinophils (p = 0.0005) and mast cells (p = 0.0001), than mono-allergic patients.
Conclusions:
The present study demonstrates that the presence of poly-allergy could define a distinct AR phenotype in comparison with mono-allergy. It could be clinically relevant as poly-allergic patients have more intense inflammation and more severe symptoms than mono-allergic ones.
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