Related Experiment Video
Updated: Apr 13, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.8K
Primary mediastinal (thymic) B-cell lymphoma presenting as cutaneous vasculitis
Adriana De Sousa Lages1, Helder Esperto2, Lèlita Santos2
1Department of Endocrinology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
BMJ Case Reports
|May 4, 2015
Summary
This case report highlights a rare instance of cutaneous small vessel vasculitis linked to thymic diffuse large B-cell lymphoma (DLBL). Early diagnosis and treatment of the underlying lymphoma are crucial for managing vasculitis symptoms.
Area of Science:
- Immunology
- Oncology
- Dermatology
Background:
- Cutaneous small vessel vasculitis (CSVV) is a neutrophilic vascular inflammation.
- Neoplasms are an infrequent cause of secondary CSVS, accounting for 2-5% of cases.
Observation:
- A 52-year-old male presented with respiratory symptoms, myalgia, and characteristic purpuric skin lesions.
- Diagnostic imaging revealed a mediastinal mass, later identified as thymic diffuse large B-cell lymphoma (DLBL).
Findings:
- The patient's symptoms and skin lesions improved with symptomatic treatment.
- Histological analysis confirmed DLBL of the thymus as the underlying cause of secondary vasculitis.
Implications:
- This case underscores the importance of investigating neoplasms in secondary cutaneous vasculitis.
- Prompt diagnosis and management of the associated lymphoma are vital for patient outcomes.
Related Concept Videos
01:16Primary Lymphoid Organs
16.9K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.9K
01:15Secondary Lymphoid Organs
10.5K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.5K
01:25Endocarditis II: Clinical Features of Infective Endocarditis
855
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
855