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Loperamide dependence and abuse.

Ryan MacDonald1, Jason Heiner2, Joshua Villarreal3

  • 1Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington, USA.

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|May 4, 2015
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Summary
This summary is machine-generated.

Loperamide, an over-the-counter antidiarrheal, can be misused for opiate-like effects, leading to dependence. Physicians must recognize this potential for misuse and dependence, which mimics opioid use symptoms.

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Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Toxicology

Background:

  • Loperamide is a widely available over-the-counter antidiarrheal medication.
  • It is generally considered safe and lacks recognized abuse potential at standard doses.

Observation:

  • A case report details a 26-year-old male experiencing loperamide dependence.
  • The patient was ingesting massive daily doses (800 mg/day) to achieve opiate-like effects.

Findings:

  • This case highlights the potential for loperamide misuse and dependence.
  • High-dose loperamide ingestion can produce euphoric effects, with information on achieving these effects being accessible.
  • Symptoms of loperamide dependence can mimic those of opioid use disorder.

Implications:

  • Physicians need to be aware of the potential for loperamide misuse and dependence.
  • Recognition of loperamide misuse is crucial for appropriate patient management and detoxification referrals.
  • This case underscores the importance of monitoring medication use, even for seemingly safe over-the-counter drugs.