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Immunoadsorption with regenerating systems in neurological disorders --A single center experience
Bernd Hohenstein1, Jens Passauer2, Tjalf Ziemssen3
1Extracorporeal Treatment and Apheresis Center, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.
Regenerating adsorber systems offer an effective alternative to plasma exchange for neurological disorders. This approach successfully reduces immunoglobulins and antibodies with few adverse events, providing a promising long-term treatment option.
Area of Science:
- Neurology
- Immunology
- Biomedical Engineering
Background:
- Immunoadsorption is an emerging alternative to therapeutic plasma exchange for neurological conditions.
- Most current data involves single-use tryptophan adsorbers, with limited information on regenerating systems.
Purpose of the Study:
- To systematically evaluate the use of a regenerating adsorber system in diverse neurological disorders.
- To assess the efficacy and safety of regenerating adsorbers for immunoglobulin and antibody reduction.
Main Methods:
- Application of a regenerating adsorber system in patients with multiple sclerosis, encephalitis, myasthenia gravis, and chronic inflammatory demyelinating polyneuropathy.
- Monitoring of immunoglobulin levels and antibody clearance.
- Assessment of adverse events.
Main Results:
- The regenerating adsorber system achieved successful reduction of immunoglobulins and antibodies across various neurological indications.
- Treatment success was observed even in disorders without identified specific antibodies, such as multiple sclerosis.
- The system demonstrated a low rate of adverse events.
Conclusions:
- Regenerating adsorber systems are effective and safe for treating a range of neurological disorders.
- These systems offer a viable and potentially more efficacious long-term treatment strategy compared to single-use adsorbers.
- Immunoadsorption with regenerating systems is suitable for both antibody-specific and non-specific neurological conditions.
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