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Related Experiment Videos

Amyloidosis in pigtailed macaques (Macaca nemestrina): pathologic aspects.

M M Slattum1, C C Tsai, R F DiGiacomo

  • 1Division of Animal Medicine, School of Medicine, University of Washington, Seattle 98195.

Laboratory Animal Science
|November 1, 1989
PubMed
Summary

Amyloidosis, a protein buildup, was found in nearly 75% of pigtailed macaques. Its prevalence varied by organ and age, with intestinal inflammation and enteritis increasing risk for this condition.

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Area of Science:

  • Veterinary Pathology
  • Primate Research
  • Comparative Pathology

Background:

  • Amyloidosis is a condition characterized by the abnormal deposition of amyloid proteins in various organs.
  • Pigtailed macaques (Macaca nemestrina) are a relevant model for studying age-related diseases.
  • Understanding amyloidosis in non-human primates can provide insights into human disease processes.

Purpose of the Study:

  • To investigate the pathologic aspects and prevalence of amyloidosis in pigtailed macaques.
  • To identify factors associated with amyloid deposition in this primate population.
  • To characterize the type of amyloid found in affected animals.

Main Methods:

  • Retrospective analysis of 248 cases of amyloidosis in pigtailed macaques.

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  • Histopathologic examination of affected tissues (spleen, liver, gastrointestinal tract).
  • Histochemical testing for amyloid typing (Type AA).

    • Main Results:

    • Amyloid was detected in the spleen, liver, and/or gastrointestinal tract in nearly 75% of the macaques studied.
    • Amyloid occurrence showed age-related variations: decreasing in the spleen and GI tract, but increasing in the liver.
    • Intestinal inflammation, retroperitoneal fibromatosis, enteritis, enterocolitis, and glomerulonephritis were significantly associated with gastrointestinal amyloid deposition.
    • Forty cases with chronic diarrhea were identified as having Type AA amyloid.

    Conclusions:

    • Amyloidosis is a common finding in aged pigtailed macaques, affecting multiple organs.
    • Specific inflammatory conditions and age are key factors influencing amyloidosis development in these primates.
    • Type AA amyloid is the predominant form in macaques presenting with chronic diarrhea.