Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

6.1K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.1K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.4K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cation-templated synthesis of a Fe<sub>4</sub>Co<sub>20</sub> cyanometallate cluster.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Glass-like anomalies and unconventional thermoelectric transport in chimney ladder crystals.

Nature communications·2026
Same author

Exceptional Rare-Earth Half-Heusler Thermoelectrics With Sublattice Softening.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Interface Excitons in van der Waals Sandwich Heterostructures.

ACS nano·2026
Same author

Pressure-Induced Superconductivity in the Thermoelectric Semiconductor Mg<sub>3</sub>Sb<sub>2</sub>.

Journal of the American Chemical Society·2026
Same author

circTMEM230 Sponges miR-223-3p to Promote Endplate Chondrocyte Extracellular Matrix Synthesis and Attenuate Tension-Induced Disc Degeneration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Related Experiment Video

Updated: Apr 13, 2026

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

15.5K

Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function.

Shao-Lin Zeng1, Li-Hui Wang1, Ping Li1

  • 1Department of Respiratory Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China.

Molecular Medicine Reports
|May 5, 2015
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) show promise for treating asthma by targeting airway dendritic cells (DCs). MSCs reduce DC maturation and migration, thereby suppressing the allergic T helper type 2 (Th2) immune response in asthma models.

More Related Videos

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

3.7K
Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

11.2K

Related Experiment Videos

Last Updated: Apr 13, 2026

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

15.5K
Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

3.7K
Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

11.2K

Area of Science:

  • Immunology
  • Cell Biology
  • Respiratory Medicine

Background:

  • Mesenchymal stem cells (MSCs) are explored for autoimmune disease treatment.
  • The role of MSCs in asthma pathogenesis and immune modulation requires further clarification.
  • Airway dendritic cells (DCs) are key players in allergic asthma development.

Purpose of the Study:

  • To investigate the immunomodulatory effects of MSCs on airway dendritic cells in a mouse model of asthma.
  • To determine if MSCs can suppress asthma features by targeting lung myeloid DCs.

Main Methods:

  • Utilized a mouse model of asthma.
  • Transplanted MSCs into asthmatic mice.
  • Analyzed the function, maturation, and migration of lung myeloid DCs.
  • Assessed T helper type 2 (Th2) cell responses and chemokine production.

Main Results:

  • MSC transplantation suppressed asthma features in the mouse model.
  • MSCs inhibited the maturation and migration of lung DCs to mediastinal lymph nodes.
  • MSC-treated DCs showed reduced capacity to activate naive and effector Th2 cells.
  • Production of Th2-attracting chemokines (CCL17, CCL22) to the airways was decreased.

Conclusions:

  • MSCs suppress asthma by targeting the function of lung myeloid DCs.
  • MSC therapy holds potential for treating asthma by modulating DC function and Th2 responses.