Related Experiment Video
Updated: Apr 13, 2026

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
Published on: May 24, 2018
Metabolic Syndrome Sinkholes: What to Do When Occam's Razor Gets Blunted
Ross D Feldman1, Todd J Anderson2, Rhian M Touyz3
1Robarts Research Institute, London, Ontario, Canada; Department of Medicine, Western University, London, Ontario, Canada; Department of Physiology & Pharmacology, Western University London, Ontario, Canada.
Abstract:
The real promise of the metabolic syndrome concept was the opportunity to elucidate a singular common mechanism for its component abnormalities and consequently a singular therapy. That promise has not produced. This relates to the following considerations: (1) metabolic syndrome remains a syndrome not a disease, (2) its diagnosis offers little more than what can be determined by measuring waist circumference, (3) risk assessment is not improved by the diagnosis of metabolic syndrome, (4) the diagnosis of metabolic syndrome does not impact the treatment of each component of the syndrome, and (5) there is no effective therapy for metabolic syndrome in its entirety.
Related Concept Videos
Confounding in Epidemiological Studies
Causality in Epidemiology
Coronary Artery Disease I: Introduction
Receiver Operating Characteristic Plot
Bias in Epidemiological Studies
MALDI-TOF Mass Spectrometry

