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Simultaneous fMRI and Electrophysiology in the Rodent Brain
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BOLD fMRI Correlation Reflects Frequency-Specific Neuronal Correlation.

Joerg F Hipp1, Markus Siegel1

  • 1Centre for Integrative Neuroscience, University of Tübingen, Otfried-Müller-Str. 25, 72076 Tübingen, Germany; MEG Center, University of Tübingen, Otfried-Müller-Str. 47, 72076 Tübingen, Germany.

Current Biology : CB
|May 5, 2015
PubMed
Summary
This summary is machine-generated.

BOLD fMRI correlations reflect specific neuronal activity frequencies. This study links hemodynamic signals to neuronal oscillations, revealing their relationship across the human brain.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Neuroimaging

Background:

  • Blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is used to study brain-wide correlations as a proxy for integrated brain functions.
  • The precise relationship between the correlation structure of hemodynamic signals (BOLD fMRI) and neuronal activity remains unclear.

Purpose of the Study:

  • To investigate the link between BOLD fMRI correlation structure and neuronal correlation structure in the human brain.
  • To determine how frequency-specific neuronal activity relates to hemodynamic correlations across the cortex.

Main Methods:

  • Simultaneous recording of BOLD fMRI and source-localized magnetoencephalography (MEG) in resting humans.
  • Analysis of spatially co-registered data to compare hemodynamic and electrophysiological correlation patterns.
  • Investigation of frequency-specific correlations across different cortical connections.

Main Results:

  • BOLD correlations across the cortex directly reflect the co-variation of frequency-specific neuronal activity.
  • The relationship between electrophysiological and hemodynamic correlations is subject-specific and persists at the centimeter scale.
  • After correcting for signal-to-noise ratios, the link between BOLD and neuronal correlations spans a broad frequency range (2-128 Hz), not just alpha-beta bands.
  • The specific neuronal oscillation frequency most related to BOLD correlation varies across different cortico-cortical connections.

Conclusions:

  • This study provides direct evidence for the neuronal basis of BOLD correlation structure.
  • BOLD correlations reflect diverse neuronal network processes occurring at different frequencies.
  • Frequency-specific electrophysiological correlations offer complementary insights into large-scale neuronal interactions beyond BOLD fMRI.