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Correlation of creatine kinase with patency of stents using coronary computed tomography angiography
Ying-na Li1, Xiang Song1, Fang Wu1
1Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.
Insights
Elevated creatine kinase levels indicate a higher risk of non-patent coronary drug-eluting stents. This finding suggests creatine kinase may serve as a predictor for long-term stent patency.
Area of Science:
- Cardiology
- Biomarkers
- Medical Imaging
Background:
- Drug-eluting stents (DES) are crucial for maintaining coronary artery patency.
- Long-term patency of DES can be affected by various factors, including inflammation and oxidative stress.
- Biomarkers that predict stent patency are essential for patient management.
Purpose of the Study:
- To investigate the correlation between serum creatine kinase (CK) levels and the long-term patency of coronary drug-eluting stents.
- To determine if CK is an independent predictor of stent non-patency.
Main Methods:
- Retrospective analysis of clinical data from 74 patients with coronary computed tomography angiography after DES implantation.
- Patients were categorized into patency and non-patency groups based on angiography findings.
- Serum CK and CK isoenzyme levels were measured and analyzed using statistical tests, including logistic regression.
Main Results:
- Patients with non-patent stents exhibited significantly higher serum CK and CK isoenzyme levels compared to those with patent stents.
- Logistic analysis identified serum CK level as an independent predictor of stent patency (OR=1.573, P=0.039).
Conclusions:
- Serum creatine kinase is an independent risk factor associated with stent non-patency.
- Elevated CK levels may indicate a higher risk of long-term stent failure.
Objective:
To explore the potential correlation between creatine kinase and the long-term patency of coronary drug eluting stents.
Methods:
The clinical data of 74 patients who had undergone coronary computed tomography angiography after drug eluting stents implantation were retrospecpectively analyzed. Based on the computed tomography angiography findings,these patients were divided into patency group and non-patency group. The mean follow-up time was (20.5 ± 13.1) months. The serum levels of creatine kinase and creatine kinase isoenzyme were measured to determine the relationship of stent patency with these oxidative-related biomarkers after long-term follow-up. The T test or non-parametric test was adopted to compare the intergroup difference of measurement data,whereas chi-square test was conducted to test the difference of enumeration data. Logistic regression was adopted to analyze the biochemical indexes and clinical information. Only variables with a P value of less than 0.05 in the univariable analyses entered the multivariate Logistic regression model.
Results:
Patients in the non-patency group had significantly higher serum creatine kinase level compared with patients in patency group [(115.5 ± 51.5)U/L vs.(75.9 ± 29.4)U/L, P=0.012] and significantly higher level of creatine kinase isoenzyme [(3.5 ± 5.3)U/L vs.(1.7 ± 1.3)U/L,P=0.034]. Furthermore,the Logistic analysis showed that serum creatine kinase level (odds ratio=1.573,95% CI=1.022-2.421, P=0.039)was an independent predictor of stent patency.
Conclusion:
Creatine kinase is an independent risk factor associated with stent non-patency.
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