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Cancer/Testis Antigen PASD1 Silences the Circadian Clock

Alicia K Michael1, Stacy L Harvey1, Patrick J Sammons1

  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.

Molecular Cell
|May 5, 2015
PubMed
Summary

The cancer/testis antigen PASD1 suppresses daily circadian rhythms by interacting with the CLOCK:BMAL1 complex. Oncogenic transformation can induce PASD1, linking cancer to disrupted circadian rhythms.

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