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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Updated: Apr 13, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Nano-plasmonic exosome diagnostics.

Hyungsoon Im¹, Huilin Shao, Ralph Weissleder

¹Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Expert Review of Molecular Diagnostics

|May 5, 2015

Summary

This summary is machine-generated.

Exosomes show promise as biomarkers, but analysis is difficult. Miniaturized systems and nano-plasmonic assays offer label-free detection for easier exosome studies.

Keywords:

cancer exosome extracellular vesicles molecular diagnosis surface plasmon resonance

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Last Updated: Apr 13, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

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Published on: May 24, 2019

An Innovative Method for Exosome Quantification and Size Measurement

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Published on: January 17, 2015

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Area of Science:

Biotechnology
Nanotechnology
Biomarker Discovery

Background:

Exosomes are valuable biomarkers found in biofluids.
Current exosome analysis methods require large samples and complex processing.
Miniaturized systems are being developed to simplify exosome studies.

Purpose of the Study:

To review advancements in exosome analysis technologies.
To introduce a novel nano-plasmonic assay for exosome detection.
To discuss challenges and future directions in exosome research.

Main Methods:

Development of miniaturized systems for sample preparation using microfluidics.
Utilizing a nano-plasmonic assay platform for protein analysis.
Employing surface plasmon resonance for label-free exosome detection.

Main Results:

Nano-plasmonic assay enables label-free exosome detection.
Miniaturized systems address challenges of sample volume and processing.
The reviewed platform shows potential for clinical exosome studies.

Conclusions:

Advancements in miniaturized systems and nano-plasmonic assays are crucial for clinical exosome analysis.
Label-free detection methods simplify exosome quantification.
Further improvements are needed to overcome existing challenges in exosome research.