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Are renal ciliopathies (replication) stressed out?
Gisela G Slaats1, Rachel H Giles1
1Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Abstract:
Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunction, causes NPHP.
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