Long-term histological changes in 1 millimeter polytetrafluoroethylene (Gore-Tex) prosthetic arterial grafts

Vein grafts are used extensively to repair blood vessels. However, when suitable vein segments are unavailable, alternative graft materials must be used. This study tested the suitability of 1 mm diameter polytetrafluoroethylene (PTFE) grafts for small-calibre arterial replacements. Grafts of 4 mm length were inserted microsurgically into the iliac arteries of 26 rats. The grafts were removed between 3 and 22 months postoperatively and examined with light microscopy and scanning and transmission electron microscopy (SEM:TEM). Anastomotic intimal hyperplasia was minimal, consisting of a few smooth muscle cells extending 100-200 microns onto the graft. The rest of the PTFE was covered with endothelium. In a few isolated areas, there was a subendothelial layer of smooth muscle, 2-10 cells thick. The short segments used in this study were highly successful, with an overall long-term patency rate of 80%. These grafts showed no evidence of excessive neo-intimal hyperplasia.