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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Adoptive T Regulatory Cell Therapy for Tolerance Induction.

Cecilia Cabello-Kindelan1, Shane Mackey1, Allison L Bayer2

  • 1Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136.

Current Transplantation Reports
|May 5, 2015
PubMed
Summary

Adoptive T regulatory cell (Treg) therapy shows promise for transplant recipients and autoimmunity patients. However, combination therapies are likely needed for Treg persistence and significant clinical benefit, avoiding chronic immunosuppression.

Keywords:
IL-2T regulatory cellsT-cellstolerancetransplantation

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Area of Science:

  • Immunology
  • Cell Therapy
  • Transplantation

Background:

  • Chronic immunosuppression poses risks for transplant recipients and autoimmunity patients.
  • Adoptive T regulatory cell (Treg) therapy offers a potential strategy for inducing long-lasting tolerance.
  • Current clinical trial data suggests single Treg infusions may not be sufficient for significant clinical benefit.

Purpose of the Study:

  • To evaluate the potential of adoptive T regulatory cell (Treg) therapy in inducing tolerance.
  • To explore strategies for enhancing Treg engraftment and persistence.
  • To investigate the necessity of combination therapies for Treg-based treatments.

Main Methods:

  • Review of clinical trial data involving ex vivo expanded autologous Tregs in type 1 diabetic patients.
  • Analysis of factors influencing Treg generation, homeostasis, and function.
  • Consideration of immunomodulation regimens to promote Treg persistence.

Main Results:

  • Single Treg infusions alone are unlikely to provide substantial clinical benefits.
  • Stable Treg engraftment and persistence are critical for therapeutic success.
  • Combination therapies may be required to achieve significant clinical outcomes.

Conclusions:

  • Adoptive Treg therapy holds promise but requires optimization for long-term efficacy.
  • Strategies promoting Treg persistence and function are essential.
  • Combination approaches integrating immunomodulation are likely necessary for successful Treg-based treatments in transplantation and autoimmunity.