Related Experiment Video

Updated: Apr 13, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K

Visual pathways involvement in clinically isolated syndrome in children

Vladislav Voitenkov1, Natalia Skripchenko1, Andrey Klimkin1

  • 1Scientific Research Institute of Children's Infections, Professora Popova 9, Saint-Petersburg 197122, Russia.

International Journal of Ophthalmology
|May 5, 2015
PubMed

Insights

Visual evoked potentials (VEP) reveal frequent visual pathway involvement in pediatric clinically isolated syndrome (CIS), often indicating early multiple sclerosis (MS) onset. This study highlights VEPs

Area of Science:

  • Neuroscience
  • Pediatric Neurology
  • Ophthalmology

Background:

  • Clinically isolated syndrome (CIS) is the initial presentation of multiple sclerosis (MS).
  • Early diagnosis of MS in children is crucial for timely intervention.
  • Visual pathways are frequently affected in MS, but their involvement in pediatric CIS requires further investigation.

Purpose of the Study:

  • To determine the extent and nature of visual pathway involvement in children diagnosed with CIS.
  • To assess the utility of visual evoked potentials (VEPs) in the early diagnosis of pediatric MS.
  • To differentiate between demyelination and axonal damage in affected visual pathways.

Main Methods:

  • Forty-seven pediatric patients (11-17 years) with CIS, later diagnosed with MS onset, and 30 healthy controls underwent VEP testing within 12 days of symptom onset.
  • VEP analysis focused on P100 peak latency (conduction speed) and amplitude (axonal integrity).
  • Results were compared against normative data and between patient and control groups.

Main Results:

  • Significant P100 latency prolongation, indicating slowed conduction in central visual pathways, was observed in 58% of pediatric CIS patients, including those without overt optic neuritis.
  • Reduced P100 amplitude, suggesting axonal damage, was less frequent, occurring in 29% of cases.
  • These findings suggest subclinical visual pathway dysfunction is common in early pediatric MS.

Conclusions:

  • The visual pathways are frequently affected during the onset of MS in children, primarily showing signs of demyelination.
  • Visual evoked potentials (VEPs) are effective tools for the early diagnosis of MS in pediatric populations.
  • VEP testing complements MRI in diagnosing pediatric MS, particularly in identifying subclinical visual pathway involvement.
Abstract

Keywords:
childrenclinically isolated syndromemultiple sclerosisvisual evoked potentialsvisual pathway

More Related Videos

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

9.9K
Eye Tracking Young Children with Autism09:03

Eye Tracking Young Children with Autism

Published on: March 27, 2012

46.8K

Related Concept Videos

Visual Agnosia01:12

Visual Agnosia

Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
1.8K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
11.2K
Visual System01:26

Visual System

Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
2.3K
Vision01:24

Vision

Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
61.7K