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Related Concept Videos

Knee Joint01:23

Knee Joint

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The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
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Bones of the Lower Limb: Femur and Patella01:16

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The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
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Related Experiment Video

Updated: Apr 13, 2026

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Neural Structures within Human Meniscofemoral Ligaments: A Cadaveric Study.

Chinmay M Gupte1, Daniel A Shaerf2, Ann Sandison3

  • 1Department of Mechanical Engineering, Imperial College London, London SW7 2AZ, UK ; Musculoskeletal Surgery Group, Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London W6 8RF, UK.

ISRN Anatomy
|May 5, 2015
PubMed
Summary

Neural structures, likely mechanoreceptors, were found in human knee meniscofemoral ligaments (MFLs). These findings suggest MFLs contribute to knee proprioception and neurosensory feedback.

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Area of Science:

  • Orthopedic Surgery
  • Neuroanatomy
  • Human Anatomy

Background:

  • The meniscofemoral ligaments (MFLs) are intra-articular structures in the human knee.
  • Their precise anatomical and functional roles, particularly regarding neural components, remain incompletely understood.

Purpose of the Study:

  • To investigate the presence and nature of neural structures within the human knee's MFLs.
  • To determine the potential contribution of MFLs to knee proprioception.

Main Methods:

  • Harvesting of MFLs from 8 human cadaveric knees.
  • Histological examination using Hematoxylin and Eosin (H&E) staining, S100 antibody staining for neural markers, and electron microscopy.
  • Analysis of neural component ultrastructure.

Main Results:

  • Neural structures were identified in 4 out of 9 examined MFLs via light and electron microscopy.
  • S100 staining confirmed the presence of neural components.
  • The ultrastructure of these neural elements resembled mechanoreceptors.

Conclusions:

  • Neural structures are present in the meniscofemoral ligaments, particularly near their meniscal attachments.
  • MFLs likely contribute to knee proprioception and neurosensory feedback, potentially playing an active role in joint stability.
  • This proprioceptive function may be especially significant in posterior cruciate ligament-deficient knees.