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[In vitro study of electrospun polycaprolactone/chitosan nano fiber membrane guided bone regeneration]
Ying He1, Xin Liu, Xu-yan Tang
1Stomatologic Hospital & College, Anhui Medical University; Key Lab of Oral Diseases Research of Anhui Province. Hefei 230032, Anhui Province.China.E-mail:wwhy2013@126.com.
Purpose:
To explore the effect of electrospining chitosan/polycaprolactone nano fiber membrane on regeneration of bone defects in vitro.
Methods:
Chitosan/polycaprolactone nanofiber membrane was prepared by electrospinning technique. According to alkaline phosphatase activity and Western blot results, the ability of osteogenic differentiation of cells by fiber membrane as carrier was evaluated. The data was analyzed statistically with SPSS17.0 software package.
Results:
The osteogenic differentiation capacity of electrospining chitosan/polycaprolactone nano fiber membrane was significantly higher than the control (without materials), and the difference was significant (P<0.05).
Conclusions:
Electrospinning chitosan/polycaprolactone nano fiber membrane can promote osteogenic differentiation of cells in vitro, which provides a scientific basis for clinical regeneration of bone defects.
