Recent Concise Viewpoints of Chronic Active Epstein-Barr Virus Infection
Related Experiment Video
Updated: Oct 9, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
1Hokkaido Institute of Public Health, 1-1, North 19 West 12, Kita-ku, Sapporo 060-0819, Japan. okano_m@iph.pref.hokkaido.jp.
Abstract:
Chronic active Epstein-Barr virus infection (CAEBV) is characterized mainly by prolonged or intermittent fever, lymphadenopathy and hepatosplenomegaly without definite underlying diseases at the diagnosis. Patients with CAEBV also may have various life-threatening conditions including hematological, neurological, pulmonary, cardiac, digestive tract, ocular and/or dermal disorders. Additionally, during the course of illness, they often develop hematological malignancies such as T cell, NK cell or B cell lymphoproliferative disorder (LPD) and/or lymphoma. No causative pathogenetic mechanisms have been sufficiently clarified, and additionally no promising efficacious treatment was demonstrated except for the hematopoietic stem cell transplantation (HSCT) in cases who develop T cell or NK cell LPD or lymphoma. This minireview outlines the recent development for the comprehensive viewpoints of CAEBV mainly regarding to virological, immunological, pathological and therapeutical progresses.
Related Concept Videos
Chickenpox
Arboviral Encephalitis
Cytomegalovirus Disease
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
Viral Hepatitis I: Introduction

