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Published on: April 3, 2017
Bariatric Surgery Induces Disruption in Inflammatory Signaling Pathways Mediated by Immune Cells in Adipose Tissue: A
Christine Poitou1, Claire Perret2, François Mathieu2
1Institute of Cardiometabolism And Nutrition (ICAN), Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition Department, F-75013, Paris, France; Sorbonne Universités, University Pierre et Marie Curie (UPMC), Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S 1166, Nutriomics team, F-75005, Paris, France.
Bariatric surgery reduces adipose inflammation by disrupting key immune signaling pathways. Specific molecules involved in these cascades may offer new therapeutic targets for obesity-related conditions.
Area of Science:
- Immunology
- Genomics
- Metabolic Surgery
Background:
- Bariatric surgery improves obesity comorbidities, potentially via reduced adipose inflammation.
- Molecular mechanisms underlying these benefits remain poorly understood.
Purpose of the Study:
- To investigate the molecular changes in adipose tissue following bariatric surgery.
- To identify key molecular players in the inflammatory response modulation.
Main Methods:
- RNA sequencing of adipose tissue from 22 obese women before and 3 months after bariatric surgery.
- Analysis of gene expression profiles, coexpressed gene modules, and immune signaling pathways.
Main Results:
- 1214 genes were differentially expressed post-surgery, with downregulated genes enriched in metabolic functions.
- Immune response modules (innate, adaptive, neutrophil) showed specific gene dissociations.
- Interferon-signaling pathway genes were largely preserved, except for DDX60.
Conclusions:
- Bariatric surgery-induced inflammatory state improvements may stem from disrupted immuno-inflammatory cascades.
- Specific molecules like DDX60 present potential therapeutic targets for obesity-associated inflammation.
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