Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

28.8K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
28.8K
Telomeres and Telomerase02:41

Telomeres and Telomerase

8.3K
8.3K
Replication in Eukaryotes01:29

Replication in Eukaryotes

19.3K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
19.3K
Replication in Eukaryotes02:31

Replication in Eukaryotes

208.5K
Overview
208.5K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.6K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.5K
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The protective effect of S-adenosylmethionine on chronic adolescent stress-induced depression-like behaviors by regulating gut microbiota.

European journal of pharmacology·2024
Same author

Selective Hydrogenolysis Conversion of Polyethylene into Alkyl Oil Over Iridium-based Catalyst.

ChemSusChem·2024
Same author

Functional Characterization of Six Eukaryotic Translation Initiation Factors of <i>Toxoplasma gondii</i> Using the CRISPR-Cas9 System.

International journal of molecular sciences·2024
Same author

Research on ride comfort optimization of the vehicle considering the subframe.

Science progress·2024
Same author

First report of PST-producing Microseira wollei from China reveals its novel toxin profile.

Harmful algae·2024
Same author

Amino-Acid-Encoded Supramolecular Nanostructures for Persistent Bioluminescence Imaging of Tumor.

Advanced healthcare materials·2024
Same journal

Invaders taking over-Mollusc faunal change in volcanic barrier lakes of the Albertine Rift biodiversity hotspot.

PloS one·2026
Same journal

AI-driven molecular diversification and ligand-based optimization of macitentan derivatives targeting VEGFR1 and endothelin signaling pathways.

PloS one·2026
Same journal

Performance patterns and records in the world aquatics masters championships: Where do the most frequently represented nations among the top-ten masters swimmers come from?

PloS one·2026
Same journal

Modeling diurnal Temperature-Rainfall relationships under multicollinearity using PLS-SEM: A case study of Ghana.

PloS one·2026
Same journal

Organizational culture, social capital, and emergency capacity in primary healthcare institutions: A cross-sectional structural equation modeling study comparing ordinary and older communities.

PloS one·2026
Same journal

Impact of kidney function on the metabolome in the general population.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Apr 13, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.6K

Does Reproductive Investment Decrease Telomere Length in Menidia menidia?

Jin Gao1, Stephan B Munch2

  • 1Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, United States of America.

Plos One
|May 5, 2015
PubMed
Summary
This summary is machine-generated.

Investing in reproduction may shorten telomeres. More fecund Atlantic silversides had shorter telomeres and reduced life expectancy, suggesting a trade-off between reproduction and telomere maintenance.

More Related Videos

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

3.3K
Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

3.8K

Related Experiment Videos

Last Updated: Apr 13, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.6K
Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

3.3K
Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

3.8K

Area of Science:

  • Life history theory
  • Gerontology
  • Evolutionary biology

Background:

  • Finite resources necessitate trade-offs in life history traits.
  • Telomere length, a biomarker of aging, requires energy for maintenance.
  • Potential trade-off between telomere maintenance and other life history traits.

Purpose of the Study:

  • Investigate the relationship between growth, fecundity, life expectancy, and relative telomere length.
  • Test the hypothesis that telomere maintenance trades off against reproductive output.

Main Methods:

  • Utilized natural variation within laboratory populations of Atlantic silversides (Menidia menidia).
  • Analyzed data on growth, fecundity, life expectancy, and relative telomere length.

Main Results:

  • No clear correlation was found between telomere length and age in Atlantic silversides.
  • Higher fecundity in fish was associated with reduced life expectancy.
  • Fish with higher fecundity exhibited shorter telomere lengths.

Conclusions:

  • Results support the hypothesis of a trade-off between reproductive investment and telomere maintenance.
  • Reproductive output may come at the cost of cellular aging, as indicated by telomere length.
  • This trade-off has implications for understanding aging and life history strategies in fishes.