Related Experiment Video

Updated: Apr 13, 2026

A Treatment Package without Escape Extinction to Address Food Selectivity
04:23

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

12.2K

Behavioral and nutritional treatment for preschool-aged children with cystic fibrosis: a randomized clinical trial

Scott W Powers1, Lori J Stark1, Leigh A Chamberlin2

  • 1Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

JAMA Pediatrics
|May 5, 2015
PubMed

Insights

Behavioral and nutritional intervention significantly improved energy intake and height in children with cystic fibrosis (CF). This approach shows promise for improving growth in young CF patients.

Area of Science:

  • Pediatric Gastroenterology
  • Nutritional Science
  • Clinical Trial Research

Background:

  • Optimal energy intake and growth are critical for preschool-aged children with cystic fibrosis (CF).
  • Evidence-based treatments are needed to address nutritional challenges in young CF patients.

Purpose of the Study:

  • To evaluate the efficacy of a behavioral and nutritional intervention compared to an education control in improving energy intake and growth metrics in preschool-aged children with CF.
  • To assess the impact of the intervention on weight z-score (WAZ) and height z-score (HAZ).

Main Methods:

  • A randomized clinical trial involving 78 children aged 2-6 years with CF and pancreatic insufficiency.
  • Intervention group received individualized nutritional counseling and behavioral child management skills training.
  • Control group received education as a behavioral placebo; both delivered in-person or via telehealth over 6 months.

Main Results:

  • The intervention group showed a significantly greater increase in daily energy intake (485 kcal vs 58 kcal) compared to the control group (P < .001).
  • A significant improvement in height z-score (HAZ) was observed in the intervention group at 18-month follow-up (adjusted difference, 0.14 units; P = .049).
  • No significant difference was found in weight z-score (WAZ) between the groups at 6 months.

Conclusions:

  • Behavioral and nutritional intervention effectively improved energy intake and height z-scores in preschool-aged children with CF.
  • The findings suggest that this intervention is a potentially efficacious nutritional strategy for young children with CF and pancreatic insufficiency.
  • Further research may explore long-term impacts and WAZ score improvements.
Abstract

More Related Videos

Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome07:38

Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome

Published on: August 3, 2021

2.9K
Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

695

Related Concept Videos

Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
636
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
663
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1.1K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
517
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
694