Related Experiment Video
Updated: Apr 13, 2026
09:37
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
10.6K
GXD: a community resource of mouse Gene Expression Data
Constance M Smith1, Jacqueline H Finger, Terry F Hayamizu
1The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Summary
The Gene Expression Database (GXD) provides comprehensive mouse gene expression data, aiding research into development and disease. It integrates diverse data types, enabling deeper biological insights and experimental design.
Area of Science:
- Developmental Biology
- Genomics
- Bioinformatics
Background:
- Understanding gene function is crucial for deciphering developmental processes and disease mechanisms.
- Comprehensive gene expression data is essential for biological research.
Purpose of the Study:
- To present the Gene Expression Database (GXD) as a valuable resource for mouse gene expression information.
- To facilitate research into the molecular basis of human development and disease through mouse models.
Main Methods:
- Curated collection of gene expression data from scientific literature and direct researcher submissions.
- Inclusion of diverse data types: RNA in situ hybridization, immunohistochemistry, RT-PCR, northern and western blots.
- Integration with the Mouse Genome Informatics (MGI) resource for combined genetic, functional, and phenotypic data.
Main Results:
- GXD contains nearly 1.5 million expression results for over 13,900 genes.
- Over 265,000 images of expression data are available for user interpretation.
- The database supports searching by various parameters and discovering new data connections.
Conclusions:
- GXD offers critical insights into gene functions, development, differentiation, and disease mechanisms.
- The database empowers researchers to evaluate expression data in a broader biological context.
- GXD facilitates the design of new experiments by revealing novel data connections.
