Related Experiment Video

Updated: Apr 13, 2026

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
06:15

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

1.5K

Post-infectious bronchiolitis obliterans and mannose-binding lectin insufficiency in Argentinean children

Verónica Giubergia1, Maximiliano Salim1, Jesica Fraga2

  • 1Pulmonology Department, Prof. Dr. Juan P. Garrahan Pediatric Hospital, Buenos Aires, Argentina.

Respirology (Carlton, Vic.)
|May 6, 2015
PubMed

Insights

Children with insufficient Mannose-binding lectin (MBL) levels are more prone to developing severe post-infectious bronchiolitis obliterans (PIBO). This genetic factor impacts disease severity in young patients with PIBO.

Area of Science:

  • Pediatric Pulmonology
  • Immunogenetics
  • Infectious Diseases

Background:

  • Post-infectious bronchiolitis obliterans (PIBO) is a severe respiratory condition in children, often following adenovirus infection.
  • Mannose-binding lectin (MBL) deficiency, linked to MBL2 gene variations, is associated with increased respiratory infection severity.
  • The role of MBL variants in PIBO susceptibility and progression requires further investigation.

Purpose of the Study:

  • To investigate the association between MBL2 gene variants and the susceptibility and clinical course of PIBO in children.
  • To compare the frequency of MBL variants in PIBO patients versus healthy controls.

Main Methods:

  • Genotyping of MBL2 gene variants (A, B, D, X) using PCR-RFLP in 111 PIBO patients and 127 healthy controls.
  • Classification of individuals into sufficient MBL (sMBL) and insufficient MBL (iMBL) groups based on MBL2 genotypes.
  • Statistical analysis to compare MBL variant frequencies and clinical outcomes between groups.

Main Results:

  • Insufficient MBL (iMBL) variants were significantly more prevalent in PIBO children (21.6%) compared to controls (10.2%).
  • PIBO patients with iMBL required intensive care and mechanical ventilation more frequently during the acute viral illness.
  • A significant association was found between MBL insufficiency and increased disease severity in PIBO.

Conclusions:

  • MBL insufficiency is more common in children with PIBO and is linked to a more severe initial presentation.
  • Innate immune defense factors, such as MBL, play a crucial role in the early stages of PIBO before adaptive immunity matures.
  • MBL2 gene polymorphisms may serve as a predictive marker for PIBO severity.
Abstract

Keywords:
childrenmannose-binding lectin polymorphismpost-infectious bronchiolitis obliterans

More Related Videos

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

21.2K
The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice12:27

The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice

Published on: April 2, 2014

17.4K

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.2K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
5.0K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
5.1K
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
60
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.2K