Related Experiment Video
Updated: Apr 13, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
Lam C Tsoi1, Sarah L Spain2,3, Eva Ellinghaus4
1Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Researchers identified five new genetic risk factors for psoriasis by analyzing over 42,000 individuals. This discovery enhances our understanding of psoriasis genetics and may lead to new treatment strategies.
Area of Science:
- Genetics
- Immunology
- Dermatology
Background:
- Psoriasis is a chronic autoimmune disease with a complex genetic basis.
- Prior studies identified 36 psoriasis susceptibility loci.
- Genome-wide association studies (GWAS) are crucial for understanding disease genetics.
Purpose of the Study:
- To identify novel genetic loci associated with psoriasis risk.
- To expand upon previous meta-analyses of psoriasis susceptibility loci.
- To integrate genetic findings with immunological pathways in psoriasis.
Main Methods:
- Conducted a large-scale meta-analysis of genome-wide association studies (GWAS) in European ancestry.
- Included over 15,000 psoriasis cases and 27,000 controls.
- Utilized refined genotype calling and imputation methods.
Main Results:
- Identified five new psoriasis susceptibility loci at genome-wide significance.
- Newly identified loci include intergenic regions (1q31.1, 5p13.1) and genes near PLCL2, NFKBIZ, and CAMK2G.
- Demonstrated NFKBIZ is a TRAF3IP2-dependent target of IL-17 signaling in keratinocytes.
Conclusions:
- The study significantly expands the number of known psoriasis genetic risk loci.
- Findings provide functional links between genetic factors and psoriasis immunology.
- Results suggest new directions for psoriasis research and therapeutic development.
More Related Videos
02:28Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
11:35Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
Published on: August 21, 2016
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Single Nucleotide Polymorphisms-SNPs
Pharmacogenomics: Identification of New Drug Targets
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Epistasis