Topical delivery of dexamethasone acetate from hydrogel containing nanostructured liquid carriers and the drug
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Updated: Apr 13, 2026

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
Nguyen-Thach Tung1, Vu-Thu Huyen2, Sang-Cheol Chi3
1Department of Pharmaceutics, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoankiem, Hanoi, Vietnam. thachtungdhd@gmail.com.
Abstract:
The potential of hydrogel containing nanostructured lipid carriers (NLC) to enhance the skin permeation rate and skin deposition of dexamethasone acetate (DEA) was investigated. The particle size of obtained NLCs was around 224.4 nm. NLCs had core-shell structure and DEA existed in amorphous state in NLCs. The permeation rate of DEA through excised mouse skins from hydrogel containing DEA-NLC (DEA-NLC-hydrogel) was 7.3 times higher than DEA-ointment. The skin deposition of DEA from DEA-NLC-hydrogel increased 3.8 folds compared to that from solution of DEA in hydrogel (DEA-hydrogel).
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