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Updated: Apr 13, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

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[Huntington's disease]

J D Rollnik1

  • 1Institut für neurorehabilitative Forschung (InFo) der BDH-Klinik Hessisch Oldendorf gGmbH, Assoziiertes Institut der Medizinischen Hochschule Hannover (MHH), Greitstr. 18-28, 31840, Hessisch Oldendorf, Deutschland, prof.rollnik@bdh-klinik-hessisch-oldendorf.de.

Der Nervenarzt
|May 6, 2015
PubMed

Insights

Huntington's disease (HD) is a progressive neurodegenerative disorder. While no cure exists, gene silencing offers a promising avenue for future Huntington's disease therapies.

Area of Science:

  • Neurology
  • Genetics
  • Neurodegeneration

Context:

  • Huntington's disease (HD) affects approximately 8000 individuals in Germany.
  • HD is a progressive neurodegenerative disorder with hyperkinetic, psychiatric, and cognitive symptoms.

Purpose:

  • Review the clinical course, epidemiology, genetics, pathophysiology, and treatment of HD.
  • Analyze current and potential therapeutic strategies for HD.

Summary:

  • Diagnostic certainty for HD is achieved through genetic testing, with CAG repeat length impacting disease progression.
  • The precise mechanism of mutant huntingtin protein (mHTT) toxicity in HD is complex, leading to neuronal cell death.
  • Clinical trials have investigated various agents, including antioxidants and receptor modulators, with limited success.

Impact:

  • Currently, no disease-modifying therapies exist for Huntington's disease.
  • Gene silencing techniques, such as RNA interference, represent a promising future direction for effective HD treatment.
Abstract

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