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[Osteomyelitis: a probable, uncommon etiology agent]
F Cuoco1, I Borzani, M Torcoletti
1UOS Reumatologia Pediatrica, Clinica Pediatrica De Marchi, IRCCS Cà Granda Ospedale Maggiore Policlino, Milano, Italia - cuoco.federica@gmail.com.
Abstract:
The relation of infectious agents to arthritis is an area of great interest to the rheumatologist. Septic arthritis of bacterial origin accounts for approximately 6.5% of all childhood arthritides. Septic arthritis usually results from haematogenous spread from a focus of infection elsewhere in the body, but also by direct extension of an infection from overlying soft tissues or bone or traumatic invasion of the joint. As a result, if a focus of underlying osteomyelitis breaks throught the metaphysis, it may enter the joint and result in septic arthritis. Systemic signs of illness are fever, severe bone pain, and tenderness with or without local swelling. A wide range of microorganism can cause septic arthritis in children; Staphylococcus aureus and nongroup A and B streptococci are most common overall. However, different organisms are more common at some ages and in certain circumstances. Kingella kingae is an emerging pathogen in young children under 4 years of age. The clinical presentation of K. kingae invasive infection is often subtle and may be associated to mild to moderate biologic inflammatory responses. Affected children often have few signs and symptoms of osteoarticular infections. Early MRI is useful in differentiating K kingae from Gram-positive cocci in osteoarticular infections. Cartilaginous involvement, modest soft tissue and bone reaction suggest K. kingae. It's very important to include K. kingae in differential diagnosis of osteoarticular infections in young children. We report an unusual case of osteomyelitis: clinical manifestations and MRI are suggestive for K kingae infection.
Insights
Kingella kingae is an emerging cause of septic arthritis in young children, often presenting subtly. Early MRI can help differentiate K. kingae from other bacterial infections in pediatric osteoarticular cases.
Area of Science:
- Pediatric Rheumatology
- Pediatric Infectious Diseases
- Pediatric Orthopedic Infections
Background:
- Septic arthritis accounts for 6.5% of childhood arthritides, often arising from hematogenous spread or direct extension of infection.
- Commonly implicated bacteria include Staphylococcus aureus and streptococci, but Kingella kingae is increasingly recognized in children under four.
- Systemic signs like fever and bone pain, alongside local tenderness, often indicate septic arthritis.
Observation:
- Kingella kingae infections in children typically present with subtle clinical signs and mild inflammatory responses.
- Affected children may exhibit few overt signs of osteoarticular infection, complicating diagnosis.
- Early Magnetic Resonance Imaging (MRI) is crucial for distinguishing K. kingae from Gram-positive cocci in osteoarticular infections.
Findings:
- Cartilaginous involvement and modest soft tissue/bone reactions on MRI suggest K. kingae.
- The subtle presentation of K. kingae necessitates its inclusion in the differential diagnosis for pediatric osteoarticular infections.
- This report details an unusual case of osteomyelitis with clinical and MRI findings suggestive of K. kingae.
Implications:
- Recognizing the subtle presentation of Kingella kingae is vital for timely diagnosis and treatment of pediatric septic arthritis.
- Advanced imaging like MRI plays a key role in differentiating K. kingae from other pathogens in children.
- This highlights the importance of considering emerging pathogens in the differential diagnosis of pediatric bone and joint infections.
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