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The brain in pain.

Asma Hayati Ahmad1, Che Badariah Abdul Aziz1

  • 1Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan.

The Malaysian Journal of Medical Sciences : MJMS
|May 6, 2015
PubMed
Summary
This summary is machine-generated.

Pain perception is subjective and influenced by context. Brain imaging reveals pain-relevant regions and a prefrontal cortex pathway modulating pain, guiding future animal studies.

Keywords:
affectivecognitivemodulationpainprefrontal cortex

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Area of Science:

  • Neuroscience
  • Pain Research

Background:

  • Pain perception is highly subjective and varies between individuals and contexts.
  • The brain network involved in pain processing includes sensory-discriminative, cognitive, and affective components.

Purpose of the Study:

  • To review neuroimaging findings on brain regions and pathways involved in pain modulation.
  • To highlight the role of the prefrontal cortex in pain modulation.
  • To establish a link between human neuroimaging data and potential molecular mechanisms in animal studies.

Main Methods:

  • Review of neuroimaging studies using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET).
  • Identification of distributed brain networks encoding pain aspects.
  • Analysis of the prefrontal cortex's role in pain modulation.

Main Results:

  • Neuroimaging identifies distributed brain regions encoding sensory, cognitive, and emotional aspects of pain.
  • The prefrontal cortex is implicated as a key modulatory area for pain.
  • A cortico-cortical pathway, distinct from descending pathways, is identified for pain modulation.

Conclusions:

  • Human neuroimaging data provides a foundation for exploring molecular mechanisms of pain modulation.
  • The prefrontal cortex plays a significant role in modulating pain perception.
  • Understanding these brain networks is crucial for advancing pain research.