Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

6.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.3K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

5.8K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.8K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

15.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
15.2K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.9K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.9K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.5K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.5K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

1.3K
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benefits Beyond Hypertension Control: Current and Evolving Treatment Strategies for Prevention of Cardiovascular Diseases.

Current hypertension reviews·2026
Same author

Normalization of Potassium Despite 11-Deoxycorticosterone Rise During Etomidate Therapy in Adrenocortical Carcinoma.

JCEM case reports·2026
Same author

DXA Derived Low Bone Mass in a Cohort of Prepubertal Eastern Indian Girls With Turner Syndrome Disappeared Following Adjustment for Short Stature.

Clinical endocrinology·2025
Same author

Prevalence of Hepatic Fibrosis and Performance of Non-invasive Liver Fibrosis Scores in an Eastern Indian Diabetic Population with NAFLD.

Journal of the ASEAN Federation of Endocrine Societies·2025
Same author

Occurrence of Nutritional Deficiencies (Ferritin, Vitamin B12, and D) and Abnormal BMI Among Women of Reproductive Age: Implications for Sustainable Food-Based Interventions.

Molecular nutrition & food research·2025
Same author

Analysis of risk factors and predictive modelling of biomarkers in subclinical hypothyroidism and implications for levothyroxine therapy in disease management.

Scientific reports·2025
Same journal

Development and Validation of a Comprehensive Obesity Assessment Tool: Integrating Lifestyle, Body Image, and Past Weight Management.

Indian journal of endocrinology and metabolism·2026
Same journal

The Indian Obesity Paradox- Low in Muscle, High in Fat.

Indian journal of endocrinology and metabolism·2026
Same journal

Serial Changes in Thyroid Hormones with Oral or Intravenous Bisphosphonates.

Indian journal of endocrinology and metabolism·2026
Same journal

Role of Serum Triiodothyronine-to-Thyroxine Ratio and Thyroid Colour Flow Doppler in Differentiation of Graves' Disease from Destructive Thyroiditis.

Indian journal of endocrinology and metabolism·2026
Same journal

Efficacy of Fixed Low-Dose Weekly Subcutaneous Testosterone Self-Administration in Transgender Male Patients in India.

Indian journal of endocrinology and metabolism·2026
Same journal

What Works in Type 2 Diabetes: Intermittent Fasting or Calorie Restriction or Both?

Indian journal of endocrinology and metabolism·2026
See all related articles

Related Experiment Video

Updated: Apr 13, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

17.5K

Puberty and type 1 diabetes.

Subhankar Chowdhury1

  • 1Department of Endocrinology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.

Indian Journal of Endocrinology and Metabolism
|May 6, 2015
PubMed
Summary
This summary is machine-generated.

Puberty significantly impacts type 1 diabetes mellitus (T1DM) management, increasing insulin resistance and risk of complications. Understanding these pubertal changes is crucial for effective T1DM care in adolescents.

Keywords:
Adolescencepubertytype 1 diabetes mellitus

More Related Videos

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.4K
Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

16.3K

Related Experiment Videos

Last Updated: Apr 13, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

17.5K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.4K
Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

16.3K

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Adolescent Medicine

Background:

  • Type 1 diabetes mellitus (T1DM) incidence peaks during puberty.
  • Puberty involves significant physiological changes impacting metabolic control and diabetes management.
  • Hormonal and metabolic shifts during puberty, including insulin resistance and growth hormone secretion, complicate T1DM care.

Purpose of the Study:

  • To review the multifaceted effects of puberty on type 1 diabetes mellitus.
  • To highlight the challenges in glycemic control and complication risks during adolescence in T1DM patients.
  • To emphasize the critical nature of this developmental phase for individuals with T1DM.

Main Methods:

  • Literature review of studies on T1DM during puberty.
  • Analysis of hormonal and metabolic changes affecting diabetes control.
  • Examination of reported complications and management strategies.

Main Results:

  • Puberty is associated with increased insulin resistance and worsened glycemic control in T1DM.
  • Physiological changes can lead to pubertal delay or complications like Mauriac syndrome.
  • Adolescent T1DM patients face a higher risk of rapid decompensation and ketoacidosis.

Conclusions:

  • Adolescence presents unique challenges for managing T1DM due to hormonal and metabolic fluctuations.
  • Effective management requires careful consideration of pubertal development and its impact on diabetes.
  • Healthcare providers, families, and patients must collaborate to navigate this critical phase.