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Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.5K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

5.8K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.8K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.9K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

15.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
15.2K
Autoimmune Disorders01:29

Autoimmune Disorders

2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.3K

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Related Experiment Video

Updated: Apr 13, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

17.5K

Type 1 diabetes mellitus-common cases.

Surender Kumar1

  • 1Department of Endocrinology, Sir Ganga Ram Hospital, New Delhi, India.

Indian Journal of Endocrinology and Metabolism
|May 6, 2015
PubMed
Summary

Strict blood sugar management in type 1 diabetes increases hypoglycemia risk. Switching to long-acting basal insulin analogs effectively reduced recurrent hypoglycemia episodes in patients, improving their quality of life.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Pharmacology

Background:

  • Tight glycemic control in type 1 diabetes mellitus (T1DM) is crucial but linked to hypoglycemia risk.
  • Diabetic patients often require significant lifestyle adjustments to manage the condition.
  • Current management strategies may not always adapt to individual patient needs, necessitating therapeutic innovation.

Purpose of the Study:

  • To investigate the efficacy of switching to long-acting basal insulin analogs in patients experiencing recurrent hypoglycemia.
  • To explore a more adaptive therapeutic approach for T1DM management.

Main Methods:

  • Case study presentation of T1DM patients with recurrent hypoglycemia.
  • Transition of patients to long-acting basal insulin analog therapy.
Keywords:
Basal insulin analoghypoglycemiatype 1 diabetes mellitus

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  • Monitoring of hypoglycemic episodes post-transition.
  • Main Results:

    • Patients experienced a significant reduction in recurrent hypoglycemic episodes after switching to long-acting basal insulin analogs.
    • Improved glycemic stability and fewer adverse events were observed.

    Conclusions:

    • Long-acting basal insulin analogs offer a viable therapeutic option for managing recurrent hypoglycemia in T1DM.
    • This therapeutic switch can help mitigate risks associated with tight glycemic control and improve patient well-being.