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Related Experiment Videos

Naltrexone blocks nicotine-induced prolactin release.

C M Flores1, B A Hulihan-Giblin, K J Kellar

  • 1Department of Pharmacology, Georgetown University Medical Center, Washington, D.C. 20007.

Neuropharmacology
|November 1, 1989
PubMed
Summary

Nicotine and morphine stimulate prolactin release through a shared pathway involving both nicotinic cholinergic and opiate receptors in rats. This indicates a complex interaction between these receptor systems in regulating prolactin secretion.

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Area of Science:

  • Neuroendocrinology
  • Pharmacology

Background:

  • Prolactin secretion is regulated by complex neural pathways.
  • Nicotinic cholinergic and opiate systems are known to influence hormone release.

Purpose of the Study:

  • To investigate the roles of nicotinic cholinergic and opiate receptors in nicotine- and morphine-induced prolactin release in conscious male rats.

Main Methods:

  • Intravenous administration of nicotine or morphine to rats with jugular cannulae.
  • Pretreatment with nicotinic antagonist mecamylamine and opiate antagonist naltrexone.
  • Measurement of plasma prolactin levels.

Main Results:

  • Both nicotine and morphine increased plasma prolactin levels.
  • Mecamylamine blocked the prolactin response to nicotine but not morphine.

Related Experiment Videos

  • Naltrexone blocked the prolactin response to both nicotine and morphine.

    • Conclusions:

    • Nicotine-induced prolactin release depends on both nicotinic and opiate receptors.
    • Nicotine and morphine appear to utilize a common pathway for prolactin release.
    • This common pathway involves sequential nicotinic cholinergic and opiate synapses.