Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amnesia and memory for modality information.

A D Pickering1, A R Mayes, A F Fairbairn

  • 1Department of Psychology, University of Manchester, U.K.

Neuropsychologia
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strategic retrieval processing and the impact of knowing when a memory was first created.

Brain and cognition·2014
Same author

Androgen levels and erythrocytosis in maturing brown trout,Salmo trutta L.

Fish physiology and biochemistry·2013
Same author

Stress responses and disease resistance in salmonid fish: Effects of chronic elevation of plasma cortisol.

Fish physiology and biochemistry·2013
Same author

The electrophysiological correlates of recent and remote recollection.

Neuropsychologia·2013
Same author

Damage to the dorsomedial thalamic nucleus, central lateral intralaminar thalamic nucleus, and midline thalamic nuclei on the right-side impair executive function and attention under conditions of high demand but not low demand.

Neurocase·2012
Same author

Storage of verbal associations is sufficient to activate the left medial temporal lobe.

Behavioural neurology·2012
Same journal

Prevalence and modulation of rat off-track head scanning on linear tracks: possible implications for representational and dynamic properties of hippocampal place cells.

Neuropsychologia·2026
Same journal

Identifying networks within an fMRI multivariate searchlight analysis.

Neuropsychologia·2026
Same journal

Modulating sentence comprehension in people with aphasia through anodal tDCS: A double-blind randomized cross-over study.

Neuropsychologia·2026
Same journal

Deficient processing of regularity violations during visuospatial neglect: a visual mismatch negativity study.

Neuropsychologia·2026
Same journal

Seeing is believing: mental imagery amplifies moral, emotional, and motivational responding to mentally constructed hypothetical events.

Neuropsychologia·2026
Same journal

From past recall to future projection: What does verb tense production reveal about mental time travel in Alzheimer's disease?

Neuropsychologia·2026
See all related articles

Controls outperformed Korsakoff amnesics in identifying word presentation modality, even when overall memory recall was matched. This suggests amnesia may involve more than just memory deficits, potentially including frontal lobe dysfunction.

Area of Science:

  • Cognitive Neuroscience
  • Neuropsychology
  • Memory Disorders

Background:

  • Korsakoff syndrome is a severe memory disorder often associated with chronic alcoholism and thiamine deficiency.
  • Previous research indicates deficits in various memory systems in amnesic patients, but the precise nature of these deficits remains debated.
  • Mixed-modality presentation (auditory and visual) can differentially affect memory encoding and retrieval.

Purpose of the Study:

  • To investigate modality-specific memory processing in individuals with Korsakoff amnesia.
  • To determine if amnesic patients can differentiate between how words were presented (read aloud vs. read silently) when overall item recognition is controlled.

Main Methods:

  • Word lists were presented in a mixed-modality format (spoken by experimenter, read by subject).

Related Experiment Videos

  • Korsakoff amnesics and matched healthy controls participated.
  • Item-memory was matched between groups using longer lists and delayed testing for controls in a forced-choice recognition task.
  • Subjects then made modality-identification judgments for recognized items.

    • Main Results:

    • While controls and amnesics were matched on item recognition accuracy, controls significantly outperformed amnesics on identifying the presentation modality of the words.
    • This indicates a specific deficit in processing or recalling information about the sensory modality of word presentation in amnesic patients.

    Conclusions:

    • The findings suggest that Korsakoff amnesia may involve impairments beyond general memory deficits, potentially affecting the processing of contextual or sensory information.
    • The observed deficit in modality identification could be linked to the core memory impairment of amnesia or potentially to co-occurring frontal lobe pathology in some amnesic patients.
    • Further research is needed to disentangle the contributions of amnesic memory deficits and potential frontal lobe dysfunction to these observed cognitive impairments.