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Updated: Apr 13, 2026

08:35
Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
20.6K
Complex wound management with an artificial dermal regeneration template.
Sean Simon, Jeff Hammoudeh, Christopher Low
1Division of Plastic Surgery, University of Miami, Miami, Florida;
Summary
Integra®, a dermal regeneration template, successfully covered an exposed tibia in a necrotizing fasciitis patient. This artificial skin substitute offers a direct alternative for complex wound coverage in challenging cases.
Area of Science:
- Plastic Surgery
- Wound Healing
- Infectious Diseases
Background:
- Necrotizing fasciitis is a severe soft tissue infection characterized by rapid necrosis of fascia and subcutaneous tissue.
- Early symptoms include disproportionate pain, erythema, and skin discoloration, progressing to systemic toxicity and sepsis.
- Diagnosis can be challenging due to limited laboratory test utility.
Purpose of the Study:
- To report the successful use of Integra®, a dermal regeneration template (DRT), as an alternative wound coverage for exposed tibia in a patient with necrotizing fasciitis.
- To highlight the potential of DRT in managing complex, exposed wounds.
Main Methods:
- Case report detailing the management of a patient with necrotizing fasciitis and significant comorbidities.
- Utilized Integra® (DRT) for coverage of an exposed tibia.
- Standard treatment included resuscitation, surgical debridement, and broad-spectrum antibiotics.
Main Results:
- Successful coverage of the exposed tibia was achieved using Integra®.
- Demonstrated the efficacy of DRT as a direct alternative for complex wound coverage.
Conclusions:
- Integra® (DRT) can serve as a viable alternative for covering exposed tibia in necrotizing fasciitis patients, even with comorbidities.
- Dermal regeneration templates offer a promising option for reconstructive surgery in complex wound management.
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