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Amnesia due to bilateral hippocampal glioblastoma. MRI finding
M Shimauchi1, S Wakisaka, K Kinoshita
1Department of Neurosurgery, Miyazaki Medical College, Japan.
Neuroradiology
|January 1, 1989
Abstract:
The authors report a unique case of glioblastoma which caused permanent amnesia. Magnetic resonance imaging showed the lesion to be limited to the hippocampal formation bilaterally. Although glioblastoma extends frequently into fiber pathways and expands into the opposite cerebral hemisphere, making a "butterfly" lesion, it is unusual for it to invade the limbic system selectively to this extent.
Insights
A rare glioblastoma case caused permanent amnesia by selectively invading the bilateral hippocampal formation. This brain tumor
Area of Science:
- Neuroscience
- Oncology
- Neuropathology
Background:
- Glioblastoma is an aggressive primary brain tumor.
- Typical glioblastoma presentation involves diffuse infiltration and potential contralateral spread.
- Limbic system involvement is uncommon in glioblastoma.
Observation:
- A unique glioblastoma case presented with permanent amnesia.
- Magnetic resonance imaging (MRI) revealed bilateral hippocampal formation lesions.
- The tumor selectively infiltrated the limbic system.
Findings:
- The glioblastoma's localization to the hippocampal formation bilaterally correlated with profound memory deficits.
- This pattern contrasts with typical glioblastoma's tendency for widespread or "butterfly" lesions.
- Selective limbic system invasion by glioblastoma is highly unusual.
Implications:
- This case highlights the critical role of the hippocampal formation in memory.
- It expands the understanding of glioblastoma's potential clinical presentations and neuroanatomical targets.
- Further research into limbic system-specific glioblastoma pathogenesis may be warranted.