Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

3.0K
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
3.0K
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

4.0K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
4.0K
Masking and Demasking Agents01:19

Masking and Demasking Agents

4.0K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
4.0K
EDTA: Auxiliary Complexing Reagents01:26

EDTA: Auxiliary Complexing Reagents

1.6K
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
1.6K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.6K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.6K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

1.3K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the Incorporation of Picolinamide Pendants into the Macropa Scaffold for Pb(II)- and Bi(III)-Based Radiopharmaceuticals.

Inorganic chemistry·2026
Same author

Isomerism and Relaxation Properties of Lanthanide(III) Complexes of a Ditopic Ligand with Two DO3A Units Bridged by a Methylene-bis(phosphinate) Spacer.

Inorganic chemistry·2026
Same author

Manganese-Templated Nontrivial Structures for MRI and Therapy.

Journal of the American Chemical Society·2026
Same author

Challenging the Macrocycle Paradigm: Four-Arm, High-Denticity Acyclic Chelators for Radiopharmaceuticals Incorporating Actinium and Lanthanides.

Inorganic chemistry·2026
Same author

Investigating Cu(II) Complexes for MRI: A Comprehensive Approach Using EPR, Relaxometry, and Computational Modeling.

Inorganic chemistry·2026
Same author

Stabilities of Ac<sup>3+</sup> Complexes Relevant as Radiopharmaceuticals.

Inorganic chemistry·2026

Related Experiment Video

Updated: Apr 13, 2026

Quantitative Atomic-Site Analysis of Functional Dopants/Point Defects in Crystalline Materials by Electron-Channeling-Enhanced Microanalysis
07:24

Quantitative Atomic-Site Analysis of Functional Dopants/Point Defects in Crystalline Materials by Electron-Channeling-Enhanced Microanalysis

Published on: May 10, 2021

7.0K

Stabilizing divalent europium in aqueous solution using size-discrimination and electrostatic effects.

Martín Regueiro-Figueroa1, José Luis Barriada2, Agnès Pallier3

  • 1†Departamento de Química Fundamental, Universidade da Coruña, Campus da Zapateira, Rúa da Fraga 10, 15008 A Coruña, Spain.

Inorganic Chemistry
|May 6, 2015
PubMed
Summary

New macrocyclic ligands selectively bind large lanthanide ions like La(3+) over smaller ones like Eu(3+). These 1,10-diaza-18-crown-6 ligands enhance selectivity and stabilize Eu(2+) against oxidation.

More Related Videos

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.5K
High-resolution Thermal Micro-imaging Using Europium Chelate Luminescent Coatings
09:01

High-resolution Thermal Micro-imaging Using Europium Chelate Luminescent Coatings

Published on: April 16, 2017

8.3K

Related Experiment Videos

Last Updated: Apr 13, 2026

Quantitative Atomic-Site Analysis of Functional Dopants/Point Defects in Crystalline Materials by Electron-Channeling-Enhanced Microanalysis
07:24

Quantitative Atomic-Site Analysis of Functional Dopants/Point Defects in Crystalline Materials by Electron-Channeling-Enhanced Microanalysis

Published on: May 10, 2021

7.0K
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.5K
High-resolution Thermal Micro-imaging Using Europium Chelate Luminescent Coatings
09:01

High-resolution Thermal Micro-imaging Using Europium Chelate Luminescent Coatings

Published on: April 16, 2017

8.3K

Area of Science:

  • Coordination Chemistry
  • Supramolecular Chemistry
  • Lanthanide Ion Complexation

Background:

  • Macrocyclic ligands are crucial for selective metal ion binding.
  • 1,10-diaza-18-crown-6 derivatives offer tunable properties for lanthanide complexation.
  • Understanding lanthanide ion selectivity is vital for applications in separation and catalysis.

Purpose of the Study:

  • To synthesize and characterize novel macrocyclic ligands based on 1,10-diaza-18-crown-6.
  • To investigate the coordination behavior and selectivity of these ligands towards lanthanide ions La(3+) and Eu(3+).
  • To evaluate the redox stability of lanthanide complexes formed with these ligands.

Main Methods:

  • X-ray crystallography for structural determination of lanthanide complexes.
  • Potentiometric titrations to determine stability constants.
  • Density Functional Theory (DFT) calculations for theoretical stability analysis.
  • Cyclic voltammetry to assess redox properties.

Main Results:

  • Two new ligands, bpa18c6 and ppa18c6(-), were synthesized and characterized.
  • X-ray structures revealed 11-coordinate complexes for La(3+) and Sr(2+).
  • Both ligands demonstrated high selectivity for La(3+) over Eu(3+), surpassing previous ligands.
  • DFT calculations supported experimental findings on ligand selectivity.
  • Cyclic voltammetry showed enhanced stabilization of Eu(2+) by bpa18c6 compared to other ligands and the aquated ion.

Conclusions:

  • 1,10-diaza-18-crown-6 based ligands exhibit excellent size-selectivity for large lanthanide ions.
  • The picolinamide pendant arms in bpa18c6 significantly enhance selectivity and redox stabilization.
  • These findings highlight the potential of tailored macrocyclic ligands in lanthanide separation and redox chemistry.