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Related Concept Videos

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Association between CD24-P226-C/T polymorphism and multiple sclerosis: a meta-analysis.

Longyang Jiang1, Xuefeng Bai, Yan Wang

  • 1School of Pharmacy, Department of Pharmacology, China Medical University , Shenyang, Liaoning , China.

Immunological Investigations
|May 6, 2015
PubMed
Summary

This meta-analysis found a significant association between the CD24-P226-C/T polymorphism and multiple sclerosis (MS) risk. Further large-scale studies are needed to confirm these findings for MS susceptibility.

Keywords:
Gene polymorphismTCF7L2meta-analysismultiple sclerosis

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Area of Science:

  • Neuroimmunology
  • Genetics
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is a complex CNS disease with unknown causes.
  • Previous studies on CD24-P226-C/T polymorphism and MS risk yielded conflicting results.

Purpose of the Study:

  • To conduct a meta-analysis assessing the association between CD24-P226-C/T polymorphism and MS risk.
  • To consolidate evidence from existing case-control studies.

Main Methods:

  • A systematic literature search identified relevant case-control studies up to July 2013.
  • Meta-analysis of odds ratios (ORs) for CD24 allele distributions in MS patients versus controls.

Main Results:

  • Seven studies (949 cases, 1177 controls) were included.
  • Significant associations were found for MS susceptibility under homozygote, dominant, recessive, and allelic models.
  • No significant association was observed in the heterozygous model.

Conclusions:

  • The CD24 P266-C/T polymorphism is associated with an increased risk of MS.
  • Larger, well-designed studies are recommended to validate this association due to the limited sample sizes in current research.