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Related Concept Videos

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Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
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Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
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Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate.

Nicolas Kambia1, Amaury Farce2, Karim Belarbi1

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Journal of Enzyme Inhibition and Medicinal Chemistry
|May 6, 2015
PubMed
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Phthalate plasticizers in medical devices are toxic. Alternative plasticizers show mixed safety results, and their metabolites' health effects remain unknown, necessitating further research.

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Area of Science:

  • Toxicology
  • Chemical Safety
  • Medical Device Materials

Background:

  • Phthalates, common plasticizers in medical devices (MDs), are recognized reproductive and developmental toxicants.
  • Their toxicity is linked to Peroxisome Proliferating-Activated Receptors (PPARs) activation.
  • European directive 2007/47/EC restricts DEHP in MDs, prompting the search for alternatives.

Purpose of the Study:

  • To identify potential PPARs-interacting compounds among phthalate alternatives.
  • To assess the toxicological profile of replacement plasticizers and their metabolites.
  • To address the lack of human health data for new plasticizers used in MDs.

Main Methods:

  • Molecular docking simulations were employed to predict interactions with PPARs binding sites.
  • In silico methods were used to identify potential metabolites of alternative plasticizers.
  • Literature review on existing toxicological and epidemiological data for alternative plasticizers.

Main Results:

  • Docking results for alternative plasticizers showed mixed predictions regarding their interaction with PPARs.
  • No toxicological or epidemiological data were found for the metabolites of these alternative plasticizers.
  • The safety of DEHP (di(2-ethylhexyl) phthalate) is primarily attributed to its metabolites, highlighting a critical knowledge gap.

Conclusions:

  • The harmlessness of alternative plasticizers is uncertain due to mixed docking results and lack of metabolite data.
  • Extensive studies on the human health effects of plasticizer metabolites are crucial before widespread adoption.
  • Current alternatives pose potential risks, necessitating cautious evaluation and further research.