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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats
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Decrease in longitudinal strain in heart transplant recipients is associated with rejection.

Helena Podrouzkova1, Helena Bedanova2, Martin Tretina2

  • 1ICRC, St. Anne's University Hospital in Brno, Czech Republic.

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|May 6, 2015
PubMed
Summary
This summary is machine-generated.

Speckle tracking strain analysis shows worsening longitudinal strain during acute cellular rejection in heart transplant patients. This non-invasive method may aid early cardiac rejection detection and optimize endomyocardial biopsy timing.

Keywords:
echocardiographygraft rejectionheart transplantation

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Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Medical Imaging

Background:

  • Heart transplant rejection affects 20-40% of patients within the first year.
  • Endomyocardial biopsy (EMB) is the gold standard for diagnosing rejection.
  • Non-invasive methods are needed for early, safe, and reliable rejection diagnosis.

Purpose of the Study:

  • To investigate speckle tracking strain analysis for diagnosing acute graft rejection.
  • To assess the potential of echocardiography-derived strain in heart transplant recipients.

Main Methods:

  • Patients undergoing EMB also had trans-thoracic echocardiography (TTE) within 2 hours.
  • Strain analysis was performed on TTEs from patients with at least two EMBs separated by ≥ 1 week.
  • The relationship between strain values and EMB results was evaluated.

Main Results:

  • A significant deterioration in longitudinal strain was observed during rejection episodes compared to non-rejection periods.
  • This finding was consistent across apical 4-chamber and 2-chamber views.
  • No significant strain changes were noted in patients without rejection on EMB.

Conclusions:

  • Worsening longitudinal strain is associated with acute cellular rejection in heart transplant patients.
  • Routine TTE-based strain analysis may facilitate early detection of cardiac rejection.
  • This technique could help in optimizing the timing of endomyocardial biopsies.