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Updated: Apr 13, 2026
Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
Published on: July 28, 2016
Oxidative markers of Myeloperoxidase and Catalase and their diagnostic performance in bipolar disorder
Salih Selek1, Abdurrahman Altindag2, Gulben Saracoglu3
1Haris County Psychiatric Center, University of Texas Health Science Center at Houston, 77021 Houston, TX, USA.
Background:
Recent researches suggest oxidative stress and generalized inflammatory state to be associated with bipolar I disorder (BID). Our aim is to evaluate Myeloperoxidase (MPO) and Catalase (CAT) activities in BID.
Methods:
73 BID patients and 73 healthy controls were enrolled. Patients were classified into manic, depressive and euthymic state. Serum MPO and CAT were measured in both patients and controls.
Results:
CAT activity was significantly lower in controls than manic, depressive and euthymics (p<0.001). MPO activity was significantly higher in controls compared to euthymics (p=0.007) and it was significantly higher in depressives compared to euthymics (p=0.023). CAT was negatively and MPO was positively correlated with disease duration in overall the patients. Positive Predictive Value was 94.5% and Negative Predictive Value was 100% above the cutoff point for CAT activity.
Conclusion:
MPO and CAT activities are impaired in BID, which may be associated with oxidative stress and inflammation.
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