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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Related Experiment Video

Updated: Apr 13, 2026

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures
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Cell division: stem cells take the stage.

Sarah M Wignall1

  • 1Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.

Current Biology : CB
|May 6, 2015
PubMed
Summary

Germline stem cells are vital for producing gametes. New live imaging reveals how these cells manage cell division and cycle control, offering fresh insights into stem cell regulation.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Stem Cell Biology

Background:

  • Germline stem cells (GSCs) are crucial for maintaining gamete production throughout an organism's life.
  • Understanding GSC division is key to understanding fertility and developmental processes.

Purpose of the Study:

  • To investigate the dynamics of mitotic progression in Caenorhabditis elegans germline stem cells.
  • To elucidate the mechanisms of cell cycle control governing GSC division.

Main Methods:

  • Utilized advanced live imaging techniques to observe GSCs in real-time.
  • Applied quantitative analysis to track mitotic progression and cell cycle events.

Main Results:

  • Observed distinct patterns of mitotic progression in GSCs.

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  • Identified key regulators involved in controlling the GSC cell cycle.

    • Conclusions:

    • The study provides novel insights into the regulation of stem cell division in the germline.
    • Findings contribute to a deeper understanding of gametogenesis and stem cell maintenance.