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Primary Cutaneous T-cell Lymphoma With Aberrant CD-20 Expression.
Journal of Drugs in Dermatology : JDD
|May 6, 2015
Summary
Primary cutaneous T-cell lymphoma with aberrant CD20 expression is rare and can be misdiagnosed. Further research is needed to understand its prognosis and potential CD20 antibody treatment.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Primary cutaneous T-cell lymphoma (CTCL) with aberrant expression of cluster of differentiation (CD) 20 is a rare entity.
- This presentation can be mistaken for B-cell lymphoma, complicating diagnosis and management.
Observation:
- A case report of a 97-year-old male with CTCL presenting with pruritic plaques and nodules.
- Biopsy revealed a dermal infiltrate of atypical T-lymphocytes with aberrant CD20 expression.
Findings:
- The patient was diagnosed with CD30-negative large T-cell lymphoma with aberrant CD20 co-expression.
- The patient passed away shortly after diagnosis, highlighting the aggressive nature of this rare condition.
Implications:
- The prognostic significance of CD20 expression in T-cell neoplasms requires further investigation.
- The potential therapeutic role of CD20-targeted therapies in CD20-positive T-cell lymphomas warrants exploration.
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