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Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine
J F C Pedrazzi1, A C Issy, F V Gomes
1Departamento de Morfologia, Estomatologia e Patologia Básica, Faculdade de Odontologia, Universidade de São Paulo, Ribeirão Preto, SP, 14049-904, Brasil.
Psychopharmacology
|May 7, 2015
Summary
Cannabidiol (CBD) and an anandamide hydrolysis inhibitor prevented amphetamine-induced disruptions in prepulse inhibition (PPI) in mice, suggesting potential antipsychotic effects mediated by the endocannabinoid system.
Area of Science:
- Neuroscience
- Psychopharmacology
- Neurobiology
Background:
- Schizophrenia is characterized by information processing deficits.
- Prepulse inhibition (PPI) is a measure of sensorimotor gating, disrupted by amphetamine in schizophrenia models.
- The endocannabinoid system and cannabinoids like CBD show potential in schizophrenia treatment.
Purpose of the Study:
- To determine if cannabidiol (CBD) pretreatment prevents amphetamine-induced PPI disruption.
- To investigate the role of anandamide and its hydrolysis inhibitor (URB597) in this effect.
Main Methods:
- Male Swiss mice were administered CBD (systemically or intra-accumbens) or URB597 prior to amphetamine exposure.
- Prepulse inhibition (PPI) tests were conducted to assess sensorimotor gating.
Main Results:
- Amphetamine disrupted PPI, while CBD and URB597 alone did not affect PPI.
- CBD pretreatment significantly attenuated amphetamine-induced PPI disruption.
- URB597 also mitigated the amphetamine-induced PPI disruption.
Conclusions:
- CBD exhibits antipsychotic-like effects, potentially acting via the nucleus accumbens.
- Increased anandamide availability may contribute to CBD's therapeutic effects in schizophrenia.
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